Jesse Hall, formerly New Academic Hall, is the main administration building for the University of Missouri. Its dome has towered 180 feet (55 m) above the south end of David R. Francis Quadrangle since its completion in 1895. In the lawn in front of Jesse Hall are The Columns, all that remains of its predecessor Academic Hall, which was destroyed by fire in 1892. The building contains the office of the chancellor, university registrar, graduate school, admissions, and financial aid. One of the most photographic landmarks in Missouri, the building was designed by Missouri architect Morris Frederick Bell, and is his largest surviving work. Jesse Auditorium had hosted graduations and many university functions over the years. The University Concert Series presents national and international concerts, Broadway shows, performers, bands, speakers, and theater to the largest auditorium in Columbia. As the former home of the School of Music, student performances occasionally take place. The building is the most prominent contributing structure to the David R. Francis Quadrangle National Register of Historic Places District. In 1922, "New Academic Hall" was renamed "Jesse Hall" in honor of retiring University President Richard Henry Jesse.

David R. Francis Quadrangle is the historical center of the University of Missouri in Columbia, Missouri. Known as The Quad, it is the oldest part of Red Campus and adjacent to Downtown Columbia at the south end of the Avenue of the Columns. At its center are six Ionic columns, all that remains of the original university building Academic Hall. Twelve buildings front the modern quadrangle including the domed main administration building Jesse Hall, the tallest building in Columbia. The Quad was designed and constructed by architect Morris Frederick Bell and his assistant William Lincoln Garver. It is named after Missouri governor David R. Francis. Eighteen structures, including the entire quad and most of Red Campus are listed as the Francis Quadrangle National Historic District. An obelisk, the original tombstone of Thomas Jefferson, stands in front of the Chancellor's Residence. It was gifted to the University by Jefferson's descendants in recognition of Missouri's ties to Virginia. In front of Jesse Hall stand markers honoring university president Richard Henry Jesse and Missouri governor David R. Francis. Nearby is another obelisk in memory of Missouri's first U.S. senator David Barton, The Missouri School of Journalism is located at the northeast corner of The Quad, comprising Walter Williams Hall, Neff Hall, Gannet Hall, along with the Reynolds Journalism Institute. To the west, Switzler Hall is the oldest academic building on campus, though the Residence on the Quad, home of the chancellor, is the oldest building overall. The University of Missouri College of Engineering completes the west side. Pickard Hall is currently closed due to radiation contamination from turn of the century experiments. Swallow Hall was recently renovated and houses the Departments of Anthropology, Visual Studies and Ancient Mediterranean Studies.