Jessie Brewer R.N. is a fictional character from the ABC Daytime soap opera General Hospital. She was played by actress Emily McLaughlin, from the show's premiere on April 1, 1963, until McLaughlin's death in 1991. On April 1, 2015, Rebecca Herbst portrayed the character in a flashback for the show's 52nd anniversary.

General Hospital is an American daytime television soap opera. It is listed in Guinness World Records as the longest-running American soap opera in production, and the second in American history after Guiding Light. Concurrently, it is the world's third longest-running scripted drama series in production after British serials The Archers and Coronation Street, as well as the world's second-longest-running televised soap opera still in production. General Hospital premiered on the ABC television network on April 1, 1963. General Hospital is the longest-running serial produced in Hollywood, and the longest-running entertainment program in ABC television history. It holds the record for most Daytime Emmy Awards for Daytime Emmy Award for Outstanding Drama Series, with 14 wins.