Jizzakh Region is one of the regions of Uzbekistan. It is located in the center/east of the country. It borders Tajikistan to the south and south-east, Samarqand Region to the west, Navoiy Region to the north-west, Kazakhstan to the north, and Sirdaryo Region to the east. It covers an area of 21,210 km2. The population is 1,443,408 with 53% living in rural areas.

Samarqand Region is the most populous region of Uzbekistan. It is located in the center of the country in the basin of the Zarafshan River. It borders Tajikistan, Navoiy Region, Jizzakh Region and Qashqadaryo Region. It covers an area of 16,773 km2. The population is estimated to be around 4,031,324, with some 63% living in rural areas (2022).