Giuseppe "Joe" Profaci was an Italian-American Cosa Nostra boss who was the founder of what became the Colombo crime family of New York City. Established in 1928, this was the last of the Five Families to be organized. He was the family's boss for over three decades.

The Five Families refer to five Italian American Mafia crime families that operate in New York City. In 1931, the five families were organized by Salvatore Maranzano following his victory in the Castellammarese War.