The John Felice Rome Center is a campus of Loyola University Chicago in Rome, Italy. The center was founded as CIVIS in January 1962, hosted on premises built for the Olympic Village of the 1960 Summer Olympics, and leased from the Italian Ministry of Foreign Affairs. In 1966 the school relocated to Monte Mario, an upscale area in northwest Rome which is the highest point in the city. After two intermediate relocations, it moved in 1978 to its present location, on Via Massimi, in a residential neighborhood on Monte Mario. In Spring 2009, Loyola University Chicago purchased the building and surrounding property, making Monte Mario the permanent home of the Rome Center.

Loyola University Chicago is a private Jesuit research university in Chicago, Illinois. Founded in 1870 by the Society of Jesus, Loyola is one of the largest Catholic universities in the United States. Its namesake is Saint Ignatius of Loyola. Loyola's professional schools include programs in medicine, nursing, and health sciences anchored by the Loyola University Medical Center. It is classified among "R2: Doctoral Universities – High research activity".