John Holmes Prentiss was an American newspaper publisher and politician in the U.S. state of New York. He represented New York's 19th congressional district in the 25th and 26th U.S. Congresses from 1837 to 1841.

New York's 19th congressional district is located in New York's Catskills, Hudson Valley, Southern Tier, and Finger Lakes regions. It lies partially in the northernmost region of the New York metropolitan area and south of Albany. This district is currently represented by Republican Marc Molinaro. It was one of 18 districts that would have voted for Joe Biden in the 2020 presidential election had they existed in their current configuration while being won or held by a Republican in 2022.