John Luther Crain is an American accountant and academic administrator and formerly served as president of Southeastern Louisiana University, having been appointed to the position on February 17, 2009, by the Board of Supervisors of the University of Louisiana System. He succeeded Randy Moffett. Crain so far has served the longest presidency at Southeastern Louisiana University and in the UL system.

Southeastern Louisiana University (Southeastern) is a public university in Hammond, Louisiana. It was founded in 1925 by Linus A. Sims as Hammond Junior College. Sims succeeded in getting the campus moved to north Hammond in 1928, when it became known as Southeastern Louisiana College. It achieved university status in 1970.