John Macleod (physiologist)
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John James Rickard Macleod, was a Scottish biochemist and physiologist. He devoted his career to diverse topics in physiology and biochemistry, but was chiefly interested in carbohydrate metabolism. H
Frederick Banting and Charles Best
Grave of Macleod and his wife at Aberdeen cemetery
Statue of Macleod in Duthie Park, Aberdeen
Insulin
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Insulin is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin gene. It is the main anabolic hormone of the body. It regulates the metabolism of carbohyd
John Macleod (physiologist)
…topics in physiology and biochemistry, but was chiefly interested in carbohydrate metabolism. He is noted for his role in the discovery and isolation of insulin during his tenure as a lecturer at the University of Toronto, for which he and Frederick Banting received the 1923 Nobel prize in Physiology or Medicine…
The structure of insulin. The left side is a space-filling model of the insulin monomer, believed to be biologically active. Carbon is green, hydrogen white, oxygen red, and nitrogen blue. On the right side is a ribbon diagram of the insulin hexamer, believed to be the stored form. A monomer unit is highlighted with the A chain in blue and the B chain in cyan. Yellow denotes disulfide bonds, and magenta spheres are zinc ions.
Two vials of insulin. They have been given trade names, Actrapid (left) and NovoRapid (right) by the manufacturers.
Charles Best and Clark Noble ca. 1920
Chart for Elizabeth Hughes, used to track blood, urine, diet in grams, and dietary prescriptions in grams