John Sanford was an early settler of Boston, Massachusetts, an original settler of Portsmouth, Rhode Island, and a governor of the combined towns of Portsmouth and Newport in the Rhode Island colony, dying in office after serving for less than a full term. He had some military experience in England, and also was an employee of Massachusetts magistrate John Winthrop's household prior to sailing to New England in 1631 with Winthrop's wife and oldest son. He lived in Boston for six years and was the cannoneer there.

The Antinomian Controversy, also known as the Free Grace Controversy, was a religious and political conflict in the Massachusetts Bay Colony from 1636 to 1638. It pitted most of the colony's ministers and magistrates against some adherents of Puritan minister John Cotton. The most notable Free Grace advocates, often called "Antinomians", were Anne Hutchinson, her brother-in-law Reverend John Wheelwright, and Massachusetts Bay Governor Henry Vane. The controversy was a theological debate concerning the "covenant of grace" and "covenant of works".