John S. Sappington (1776-1856) was an American physician known for developing a quinine pill to treat malarial and other fever diseases in the Missouri and Mississippi valleys, where the disease was widespread. He later used the pill to prevent malaria. Because he both manufactured and sold "Dr. Sappington's Anti-Fever Pills", he became wealthy from his bestseller.

John Breathitt was an American politician and lawyer who was the 11th Governor of Kentucky. He was the first Democrat to hold this office and was the second Kentucky governor to die in office. Shortly after his death, Breathitt County, Kentucky was organized and named in his honor.