John Shine is an Australian biochemist and molecular biologist. Shine and Lynn Dalgarno discovered a nucleotide sequence, called the Shine-Dalgarno sequence, necessary for the initiation of protein synthesis. He directed the Garvan Institute of Medical Research in Sydney from 1990 to 2011. From 2018 to 2022, Shine was President of the Australian Academy of Science.

The Garvan Institute of Medical Research is an Australian biomedical research institute located in Darlinghurst, Sydney, New South Wales. Founded in 1963 by the Sisters of Charity as a research department of St Vincent's Hospital, it is now one of Australia's largest medical research institutions, with approximately 750 scientists, students and support staff.