John T. Struble was a builder and farmer during the formative years of the state of Iowa. He was an older brother of two prominent Iowa politicians: Congressman Isaac S. Struble and Speaker of the Iowa House of Representatives George R. Struble.

Isaac Sterling Struble was an American politician who was a four-term Republican Representative of Iowa's 11th congressional district. Serving from 1883 to 1891, the Plymouth County resident was a noted congressional opponent of plural marriage in the Utah Territory.