Sir John Talbot of Grafton, Worcestershire was a prominent recusant English Catholic layman of the reigns of Elizabeth I of England and James I of England. He was connected by marriage to one of the Gunpowder Plot conspirators, and by acquaintance or family ties to other important Catholic figures. He fell often under suspicion from the English government.

Grafton Manor was established before the Norman Conquest. Grafton means "settlement at or near the wood" and may indicate a role in woodland management within a larger estate, for instance.