John Wayne Airport is an international commercial and general aviation airport that serves Orange County, California, and the Greater Los Angeles area. The airport is located in an unincorporated area of Orange County, and it is owned and operated by the county. John Wayne Airport is surrounded by the cities of Irvine, Newport Beach, and Costa Mesa, although its IATA airport code is registered to Santa Ana, the county seat. Originally named Orange County Airport, the Orange County Board of Supervisors renamed the airport in 1979 in honor of actor John Wayne, who lived in neighboring Newport Beach and died that year. A statue of John Wayne was installed at the airline terminal in 1982.

Orange County is a county located in the Los Angeles metropolitan area in Southern California, United States. As of the 2020 census, the population was 3,186,989, making it the third-most-populous county in California, the sixth-most-populous in the United States, and more populous than 19 American states and Washington, D.C. Although largely suburban, it is the second-most-densely-populated county in the state behind San Francisco County. The county's three most-populous cities are Anaheim, Santa Ana, and Irvine, each of which has a population exceeding 300,000. Santa Ana is also the county seat. Six cities in Orange County are on the Pacific coast: Seal Beach, Huntington Beach, Newport Beach, Laguna Beach, Dana Point, and San Clemente.