Johnny Mnemonic is a 1995 cyberpunk action film directed by Robert Longo in his feature directorial debut. William Gibson, who wrote the 1981 short story, wrote the screenplay. The film, set in 2021, portrays a dystopian future racked by a tech-induced plague, awash with conspiracies, and dominated by megacorporations and organized crime. Keanu Reeves plays Johnny, a data courier with an overloaded brain implant designed to securely store confidential information. Takeshi Kitano portrays a yakuza affiliated with a megacorporation attempting to suppress the data; he hires a psychopathic assassin played by Dolph Lundgren to do so. Ice-T and Dina Meyer co-star as Johnny's allies, a freedom fighter and a bodyguard, respectively.

Cyberpunk is a subgenre of science fiction in a dystopian futuristic setting that tends to focus on a "combination of lowlife and high tech", featuring futuristic technological and scientific achievements, such as artificial intelligence and cyberware, juxtaposed with societal collapse, dystopia or decay. Much of cyberpunk is rooted in the New Wave science fiction movement of the 1960s and 1970s, when writers like Philip K. Dick, Michael Moorcock, Roger Zelazny, John Brunner, J. G. Ballard, Philip José Farmer and Harlan Ellison examined the impact of drug culture, technology, and the sexual revolution while avoiding the utopian tendencies of earlier science fiction.