Johnson County is a county located in the U. S. state of Kentucky. As of the 2010 census, the population was 23,356, its county seat is Paintsville. The county was formed in 1843 and named for Richard Mentor Johnson, War of 1812 general, United States Representative and Vice President of the United States. Johnson County is classified as a moist county, a county in which alcohol sales are not allowed, but containing a "wet" city, in this case Paintsville, where alcoholic beverage sales are allowed. Johnson County was formed on February 24, 1843 by the Kentucky General Assembly from land given by Floyd and Morgan counties. At that time, its county seat of Paintsville had been a chartered city for nine years. Homes had been built in Paintsville as early as the 1810s. Many of the families at the beginning of Johnson County's formation were of Scottish, English, or German descent. A fact lost to most historians is the large population of French Huguenots who were confused as English because they fled via England en route to the United States.
Many of these settlers migrated from North Carolina and Virginia following their participation in the Revolutionary War. For about its first twenty-five years, Johnson County and Paintsville struggled along. Roads and highways were nonexistent. Mail and supplies reached Johnson County from the Bluegrass region by steamboat. Years stage coaches began to connect eastern Kentucky and Johnson County to the bluegrass region and the rest of civilization; as Johnson County and its county seat had begun to thrive, in 1860 the Civil War became a disrupter. Like other border areas, brothers fought against brothers. Johnson County was not only part of a border state during the Civil War, but it was a border county as well. Sometime between 1860 and 1862, the county enacted an ordinance that neither the Union or Confederate flags were to be flown within the county; this was repealed after Colonel James Garfield's Union brigade marched through Paintsville on its way to defeat the Confederate cavalry at the Battle of Middle Creek in Floyd County.
Following the Civil War, Thomas Jefferson Mayo moved to Paintsville to fulfill a role as a gifted and talented teacher. He fathered John C. C. Mayo, an important figure in the development of eastern Kentucky; the county citizenry is divided on their loyalty to his memory. Some would say he was a benefactor who assisted in the development of Paintsville, as a result, Johnson County; that he helped develop banks, streets, public utilities and railroad transportation. Others would say he was directly responsible for the huge influence coal companies had over the county's vast coal resources and the reason the region remains so economically depressed to this day. Coal was important for Johnson County and the rest of eastern Kentucky before the Civil War, but its development halted at the start of the war. Financing was slow to return to the coal industry in eastern Kentucky and this inhibited development in Johnson County; the people were suspicious of outsiders and Mayo, a school teacher, was a known quantity and one of their own.
So he was invaluable in helping the coal industry to gain a firm foothold in the coal fields of eastern Kentucky and to the industrialized north which spurred the development of railroads in the area. Carpetbaggers from the North became a common sight in the area, it was during this time that many of the citizens of Johnson County were given misleading information and sold all mineral rights to their property for pennies on the dollar of what the rights were worth. In some cases, for a new shotgun, it was during this time that many people lost their property due to a strange rash of fires in several county seats, destroying deeds and records of ownership, which paved the way for land-grabbers to take what the owners did not want to relinquish. The Chesapeake and Ohio Railway first opened its Paintsville depot on September 1, 1904, following 25 years of work connecting it to Lawrence County; the rails were paid for by donations and bonds, the hard work of local citizens. History shows that the rail companies leaked information and changed planned routes to create bidding wars and to finance the rails.
Following the development of the railroad, tens of thousands of tons of coal were being transported out of eastern Kentucky by 1910. Mayo went on to be a political lobbyist, eastern Kentucky's only member of the Democratic National Committee, he had influence in electing Kentucky's governors, members of Congress and the election of President Woodrow Wilson. He died after becoming ill following a trip to Europe. During his life, he built a historic mansion in Paintsville. According to the U. S. Census Bureau, the county has a total area of 264 square miles, of which 262 square miles is land and 2.2 square miles is water. The county's highest point is Stuffley Knob, with an elevation of 1,496 feet, its lowest point is the Levisa Fork on the Lawrence County border, with an elevation of about 550 feet. Lawrence County Martin County Floyd County Magoffin County Morgan County U. S. Route 23 U. S. Route 460 Kentucky Route 40 Kentucky Route 321 Kentucky Route 3 Big Sandy Regional Airport, located in adjacent Martin County, is the nearest airport.
It is used as a general aviation airport. The nearest airport that provides commercial aviation services is Tri-State Airport, located 55 miles northeast in Ceredo, West Virginia; as of the census of 2000, there were 23,445 people, 9,103 households, 6,863 families residing in the county. The
Beautiful Vision is the thirteenth studio album by Northern Irish singer-songwriter Van Morrison, released in February 1982. It continued Morrison's departure from R&B at the time, instead favoring Celtic folk and American jazz in its music; as with many of Morrison's recordings, spirituality is a major theme and some of the songs are based on the teachings of Alice Bailey. Other songs show Morrison's Celtic reminiscence of his Belfast background. Beautiful Vision received critical acclaim but garnered only modest chart success, peaking at number 31 on the UK album charts and number 44 on the US Billboard 200; the first recording session started in May 1981 at the Record Plant studios, California, near the Golden Gate, San Francisco. Although only "Scandinavia" was released on Beautiful Vision from this session, "Cleaning Windows" and "Celtic Ray" were re-recorded for Beautiful Vision on. All the other songs or instrumentals from the session were included on one of Morrison's albums: the instrumentals "All Saints Day" and "Daring Night" appeared with lyrics on the albums Hymns to the Silence and Avalon Sunset, "Down the Road I Go" was renamed "Down the Road" and used as the title track on Down the Road.
On 27 July Morrison entered the recording studio to record "Cleaning Windows" and "Aryan Mist". Morrison brought in different musicians for this session, including his former drummer Gary Mallaber and guitarist Mark Knopfler. Morrison concluded recording in the summer. Four songs were not used from this session, including the future singles "Real Real Gone" and "Tore Down a la Rimbaud". Neither Knopfler nor Herbie Armstrong were able to produce the guitar tone Morrison wanted, so engineer Jim Stern suggested Chris Michie: "I got the call when I was doing a session in San Francisco. Van's producer Jim Stern said'Can you get to the Plant in twenty minutes?' I said'Yeah.' I walked into the studio with my gear as the band and Van were doing... basic tracks. I was set up and playing before the end of the song'She Gives Me Religion'". Michie added lead guitar overdubs to "Cleaning Windows" and "Aryan Mist". Knopfler's contributions are not as audible as Michie's. According to the liner notes, some of the lyrics derive from the book Glamour: A World Problem by esoteric writer Alice Bailey.
It is said to have been influenced by his new girlfriend, Ulla Munch, from Vanløse in Copenhagen, Denmark. The album emphasised the distance Morrison had moved away from R&B and was inspired by Irish music, he commented at the time, "It's important for people to get into the music of their own culture... I think it can be dangerous to not validate the music of where you're from, for anybody, whether it's Bulgaria or whatever."The opening song, "Celtic Ray", was one of the first songs to be written for the album. It is concerned with the singer's connection to the ancient Celtic culture; the song has the concept of messages coming through the ether from Mother Ireland. "Northern Muse" adds a young woman in County Down to a similar theme. Morrison commented in an interview with Hot Press in 1982 that "Some of the material, when it started, was more traditional; some of the songs - like'Solid Ground' and'Celtic Ray' - they started out as folk-oriented stuff, and... ended up being integrated as folk/R&B.""Dweller on the Threshold" and "Aryan Mist" are credited to the religious writings of Alice Bailey.
Her book discusses the New Age ideas of "glamours" or "mental illusions", which formed a fog that covers the "spiritual warrior" and the "Aryan race" from the world. When the "dweller on the threshold" was covered with the light of the soul or "Angel of Presence" illumination came; some of these ideas were quoted in both co-written with Hugh Murphy. In 1982 Morrison revealed in an interview: "I've read Glamour four or five times, I get different things out of it each time.'s saying a lot of things. It's depth reading. You might read it on Wednesday and on Thursday you pick it up again and get an different thing. I don't feel qualified to speak about what it's about - you have to read it yourself... because there's so much in there.""Beautiful Vision" can be interpreted as either a vision of heaven or of his girlfriend, who influences "She Gives Me Religion" and "Vanlose Stairway". Biographer Clinton Heylin believes the songs "'Vanlose Stairway' and'She Gives Me Religion' Morrison's most captivating love songs since the days of Veedon Fleece."
"Cleaning Windows" is about Morrison's first full-time job and the last carefree days of his adolescence in the years 1961 to 1962, is a metaphor for the idea that his music alters people's perceptions of life. Biographer Steve Turner believes in this song Morrison "captured the balance between his contentment at work and his aspirations to learn more about music, it conveyed the impression that his happiness with the mundane routine of smoking Woodbine cigarettes, eating Paris buns and drinking lemonade was made possible by the promise that at the end of the day he could enter the world of books and records... ". The melody is upbeat and embellished with organ and guitar, reminiscent to the music of The Band; the song is written in a similar fashion to Morrison's 1970 song, "And It Stoned Me". It is interpreted by three of Morrison's biographers that "Across the Bridge Where Angels Dwell" is about the bridge that separated Morrison's Mill Valley, California home from the San Mateo house where his daughter, Shana and ex-wife Janet Morrison Minto lived.
Carlile Transportation Systems is a transportation company based in Anchorage, Alaska. Their primary specialty is transporting freight and supplies related to the oil exploration industry, most notably to the Prudhoe Bay oil field; the company's logo is the word "Carlile" in red italicized lettering, appears on its blue truck cabs, white cargo trailers, fuel tankers and flatbed trailers. The company operates facilities in Anchorage, Fairbanks, Kenai and Seward, as well as in Edmonton and the port cities of Tacoma and Houston, Texas; the company was founded in 1980 as Carlile Enterprises by brothers Harry and John McDonald with their two trucks. In 1985, they made their first haul to Prudhoe on the Dalton Highway. Carlile developed an "approach" in transporting loads on the Dalton, which Harry McDonald described in a 2010 interview, that keeps his drivers safe, his trucks rolling, gets the freight delivered on time and in one piece. Tom Hendrix Jr. Carlile's Vice President of Oil and Gas, tells in a 2017 interview how one of their most important clients and key partners influenced this approach: the Trans-Alaska Pipeline System.
Carlile made their first appearance on The History Channel in a July 2006 documentary called Alaska: Dangerous Territory. When they returned to History in the television series Ice Road Truckers in 2009, they were hauling 30% of all loads bound for Prudhoe Bay. Carlile would be one of the featured companies of the series from Season 3 through Season 6; the company was purchased by Seattle, Washington-based Saltchuk on May 31, 2013.<ref>Staff. "Saltchuk buys Carlile, adds to Alaska freight portfolio". Alaska Journal of Commerce. Retrieved October 26, 2017. Company homepage
Camp Joe Scherman is a 700-acre camping and recreation facility owned and operated by the Girl Scout Council of Orange County, located off the Pines to Palms Highway in Riverside County, Southern California. The camp is at 5,500 feet in elevation; the scenic property features rolling foothills of California montane chaparral and woodlands habitats below Pine Mountain, a junior Olympic-size pool, two ponds, miles of trails for hiking and exploring. Camper's' activities include backpacking, canoeing, horseback riding, arts & crafts, nature exploration, camping skills, drama, rock climbing and outdoor cooking; the land was the homeland the Cahuilla Indians, many locations in the camp have names derived from the Cahuilla language. Joe Scherman was California's first state ranger and was intimately involved in GSCOC's purchase of the property upon which Camp Scherman was established. All 700 acres were owned by James Wellman, a somewhat legendary big game hunter and good friend of Joe Scherman. Scherman helped GSCOC negotiate with Wellman for the property, in 1959 the first 560 acres were purchased for $96,500.
Eighteen years in 1977, the final 140 acres were purchased from the Wellman family to complete the property within Camp Scherman today. Upper Camp refers to the part of camp up the hill from Morris Ranch Road, the main road through camp; the Upper Camp portion contains the main kitchen. Keeway means "North Wind"; the unit consists of two-sided rustic cabins with six bunks on each side. It shares a shelter with Wabanino; the shelter is unenclosed. Keeway borders the dirt road from TC-4, making it easy to access from anywhere in camp. Two trailheads lead away from Keeway: one goes to Kitchiwani and the other goes to Adoette. Kitchiwani is a portmanteau of "Kitchino" and "Shawani", which mean West Wind. Kitchiwani called Kitchi, is the only unit in camp that has both tents and cabins; the cabins are two-sided cabins with six bunks on each side. The tents are platform tents; the Kitchi shelter is unenclosed. It contains a costume closet, used for theater units. A stage is set up on the grass and props and costumes from the Kitchi closet are used.
Kitchiwani is adjacent to TC-4, is the first unit campers see upon arrival there. It is centrally located and provides easy access to the rest of camp. Two trailheads lead away from Kitchiwani: one goes to Keeway/Wabanino and the other goes to Morris Ranch Rd. the main road through camp. Pa Solé means "Sitters on the Hill". Pa Solé called Paso, is made up of rustic cabins with four bunks; the shelter is unenclosed. Due to a lack of water pressure, Paso is not being used as a unit for campers, but is sometimes used for special events. Pa Solé sits at the top of the steepest hill in camp, just up the hill from the Dining Hall, Health Center, Holly Tree, the Ark, as well as Ribbonwood and Snoqualamie. Despite its proximity to these buildings, Pa Solé is not accessible from the rest of camp due to the hill one must climb to reach it. A major trailhead leads away from Paso, which splits into the Sr. Loop Trail, 6064, Red Rock. Ribbonwood is named for the tree of the same name, prevalent in the area, whose bark peels away in long ribbons.
Ribbonwood consists of platform tents with four beds each. Ribbonwood shares its enclosed shelter with Snoqualamie, the biffy is attached to the shelter. Ribbonwood is just past the flagpole, near the Dining Hall, Holly Tree, Health Center. A trailhead leads away from Ribbonwood to an off-property rock-climbing program area. Snoqualmie means "Moon People". Snoqualmie referred to as Snoq, is made up of rustic cabins with eight bunks each; the shelter, which it shares with Ribbonwood, is enclosed, the biffy is attached. Snoqualamie is close to the Dining Hall, Health Center, Holly Tree, as well as the main dirt road which runs through Upper Camp; because of its accessibility and convenience to the rest of camp, Snoqualmie is used for younger campers. Campers who stay there are referred to as "Snoqers". Wabanino means "East Wind", is referred to as Waba; the unit consists of two-sided rustic cabins with six bunks on each side. It shares a shelter with Keeway; the shelter is unenclosed. Wabanino borders the dirt road from TC-4, making it easy to access from anywhere in camp.
Two trailheads lead away from Wabanino: one goes to Kitchiwani and the other goes to Adoette. Whispering Winds is made up of eight-person rustic cabins; the shelter is enclosed, the biffy is attached. It lies just off the main road, downhill a bit from the Dining Hall, its accessibility to the road makes it easy to get anywhere in camp quickly. Wyeena is a platform tent unit, with four girls to a tent, it has a small unenclosed shelter. Wyeena is past Whispering Winds, set far back in the canyon, it is not accessible, therefore it takes a while to get most places in camp. Rattlesnake Trail leads away from Wyeena towards the Dining Hall. Lower Camp refers to the part of camp downhill from Morris Ranch Rd. the main road through camp. It contains most of the program areas. Adoette means "Big Trees"; the unit consists of two-sided rustic cabins with six bunks on each side. Adoette referred to as Ado, has its own enclosed shelter, but shares a biffy with nearby Tawasi. Ado is used for horseback riding units, due to its proximity to the Tack House and Arena.
Adoette is a bit far back from the road, but is convenient to
USS Hart was a Wickes-class destroyer built for the United States Navy during World War I. The Wickes class was an improved and faster version of the preceding Caldwell-class. Two different designs were prepared to the same specification that differed in the turbines and boilers used; the ships built to the Bethlehem Steel design, built in the Fore River and Union Iron Works shipyards used Yarrow boilers that deteriorated badly during service and were scrapped during the 1930s. The ships displaced 1,202–1,208 long tons at standard load and 1,295–1,322 long tons at deep load, they had an overall length of 314 feet 4 inches, a beam of 30 feet 11 inches and a draught of 9 feet 10 inches. They had a crew of 108 enlisted men. Performance differed radically between the ships of the class due to poor workmanship; the Wickes class was powered by two steam turbines, each driving one propeller shaft, using steam provided by four water-tube boilers. The turbines were designed to produce a total of 27,000 shaft horsepower intended to reach a speed of 35 knots.
The ships carried 225 long tons of fuel oil, intended gave them a range of 2,500 nautical miles at 20 knots. The ships were armed with four 4-inch guns in single mounts and were fitted with two 1-pounder guns for anti-aircraft defense, their primary weapon, was their torpedo battery of a dozen 21 inch torpedo tubes in four triple mounts. In many ships a shortage of 1-pounders caused them to be replaced by 3-inch anti-aircraft guns, they carried a pair of depth charge rails. A "Y-gun" depth charge thrower was added to many ships. Hart, named in honor of Ezekiel Hart and John E. Hart, was launched 4 July 1918. Harold Jones in command. Hart joined the destroyer force and operated off the California coast until 17 July 1920, when she was reclassified minelayer, destroyer, DM-8, proceeded to Mare Island Navy Yard for installation of minelaying equipment. Following her conversion, Hart was assigned to Mine Detachment, Asiatic Fleet, sailed for the Philippine Islands in November 1920, she subsequently operated in waters off the Philippine China in peacetime operations.
Ordered to San Diego, for deactivation, Hart sailed from Manila, 12 December 1930 and arrived at San Diego 24 January 1931. She decommissioned 1 June 1931, her name was struck from the Navy List 11 November. Hart was sold for scrap 25 February 1932 in accordance with the London Treaty for the limitation of naval armaments. Friedman, Norman. U. S. Destroyers: An Illustrated Design History. Annapolis, Maryland: Naval Institute Press. ISBN 0-87021-733-X. Gardiner, Robert & Gray, eds.. Conway's All the World's Fighting Ships: 1906–1921. Annapolis, Maryland: Naval Institute Press. ISBN 0-85177-245-5; this article incorporates text from the public domain Dictionary of American Naval Fighting Ships. The entry can be found here. NavSource Photos
In genetics and cell biology, repression is a mechanism used to decrease or inhibit the expression of a gene. Removal of repression is called derepression; this mechanism may occur at different stages in the expression of a gene, with the result of increasing the overall RNA or protein products. Dysregulation of derepression mechanisms can result in altered gene expression patterns, which may lead to negative phenotypic consequences such as disease. Transcription can be repressed in a variety of ways, therefore can be derepressed in different ways as well. A common mechanism is allosteric regulation; this is when a substrate causes it to undergo a conformational change. If the repressor is bound upstream of a gene, such as in an operator sequence it would be repressing the gene's expression; this conformational change would take away the repressor’s ability to bind DNA, thus removing its repressive effect on transcription. Another form of transcriptional derepression uses chromatin remodeling complexes.
For transcription to occur, RNA polymerase needs to have access to the promoter sequence of the gene or it cannot bind the DNA. Sometimes these sequences are wrapped around nucleosomes or are in condensed heterochromatin regions, are therefore inaccessible. Through different chromatin remodeling mechanisms these promoter sequences can become accessible to the RNA polymerase, transcription becomes derepressed. Transcriptional derepression may occur at the level of transcription factor activation. Certain families of transcription factors are non-functional on their own because their active domains are blocked by another part of the protein. Substrate binding to this second, regulatory domain causes a conformational change in the protein to allows access to the active domain; this lets the transcription factor bind to DNA and serve its function, thus derepressing the transcription factor. Derepression of translation increases protein production without altering the levels of mRNA in the cell. MiRNAs are a common mechanism of translation repression, binding to the mRNA through complementary base pairing to silence them.
Certain RNA binding proteins have been shown to target untranslated regions of the mRNAs and upregulate the translation initiation rates by alleviating the repressive miRNA effects. An example is the auxin mediated derepression of the auxin response factor family of transcription factors in plants; these auxin response factors are repressed by Aux/IAA repressors. In the presence of auxin, these Aux/AII proteins undergo ubiquitination and are degraded; this derepresses the auxin response factors. Alzheimer’s is a neurodegenerative disease involving progressive memory loss and other declines in brain function. One common cause of familial Alzheimer’s is mutation in the PSEN1 gene; this gene encodes a protein that cleaves certain intracellular peptides which, once free in the cytoplasm, promote CBPdegradation. Mutations in PSEN1 decrease its ability to cleave proteins; this derepresses the CBP proteins, allows them to perform their function of upregulating transcription of their target genes. Rhett syndrome is a neurodevelopmental disorder involving deterioration of learned language and motor skills and seizures starting in infancy.
Many cases of Rhett syndrome are associated with mutations in MECP2, a gene encoding a transcriptional repressor. Mutations in this gene decrease the levels of MeCP2 binding to different promoter sequences, resulting in their overall derepression; the increased expression of these MeCP2 regulated genes in neurons contribute to the Rhett syndrome phenotype. This syndrome is associated with an increased susceptibility of tumors and growth abnormalities in children. A common cause of this syndrome is a mutation in an imprint control region near the Igf2 gene; this imprint control region is bound by an insulator on the maternal allele, which represses an enhancer from acting on the Igf2 gene. This insulator allows it access to the gene. Mutations in this imprint control region inhibit the insulator from binding, which derepresses enhancer activity on the maternal Igf2 gene; this abnormal derepression and increase in gene expression can result in Beckwith-Wiedemann syndrome