Jorge Abner Drexler Prada is a Uruguayan musician and doctor specializing in otolaryngology. In 2004, Drexler won wide acclaim after becoming the first Uruguayan to win an Academy Award, which he won for composing the song "Al Otro Lado del Río" from The Motorcycle Diaries. Drexler was born in Montevideo. In 1939 his father, a German Jew, fled to Uruguay with his family at the age of four to escape the Holocaust, his family fled to Bolivia and lived there. At the time, only Bolivia among South American countries was open to Jewish immigrants, and over six decades as his gratitude to Bolivia he made a song, included in Bailar en la Cueva. His mother is a Christian of mixed Spanish and Portuguese descent. Drexler does not follow any organized religion. Like much of his family, he studied medicine and became an otolaryngologist—an ear and throat specialist. Drexler began playing piano before attending guitar and composition classes. Although he had an interest in music, he became a doctor like both of his parents.
He attended medical school in Montevideo. During his time in medical school, Drexler took a break to hitchhike through Brazil, he studied music and recorded two albums, which were only released in Uruguay. In 1995 he was invited to Madrid by well-known Spanish songwriter Joaquín Sabina, who introduced him to other important Spanish singers. Drexler went to Spain to record the album Vaivén in 1996 with Spanish musicians. Vaivén included some old songs from his previous releases mixed with new compositions, he moved to Spain and recorded another four albums: Llueve, Frontera and Eco. In 2001, Drexler co-wrote two songs for Spanish singer Rosario Flores for her album Muchas Flores. Drexler's song "Al Otro Lado del Río" appeared in the internationally acclaimed film The Motorcycle Diaries. Though Drexler himself sang the song on the movie soundtrack, he was not allowed to perform the song at the 2005 Academy Awards, since "he was not popular enough," according to Spanish newspaper El País. Upon winning, Drexler recited two verses of the song at the podium.
Drexler became the first Uruguayan to win an Academy Award. After that, he released 12 Segundos de Oscuridad. Although he lives most of the year in Spain, his albums were recorded in Uruguay with Uruguayan musicians. Juan Campodónico and Carlos Casacuberta, former members of rock band El Peyote Asesino, had produced Drexler's albums from Frontera to 12 Segundos De Oscuridad. In 2008, he released a double live album, recorded in diverse concerts in Spain: Cara B filled with songs unreleased. During 2009, Drexler worked with Colombian performer Shakira on the Spanish-language versions of her singles "She Wolf", "Did it Again" and "Waka Waka. Drexler recorded Amar la Trama from November 1–4, 2009 in Madrid, Spain in just four days, with musicians playing live on studio. Drexler described the album without "the melancholy and anguish" of 12 Segundos. Amar la Trama was recorded in a television studio in front of a small audience who were selected in an online contest, he chose this format to avoid the "coldness" of the recording studio.
His album "Bailar en la cueva", released in 2014, shows a new facet of the artist leaning towards rhythm and dance, a contrast to his previous albums which he describes as more introspective and nostalgic. In particular, he has pointed out that it is a different album to the last one, describing it as the opposite pole to "Amar la Trama", his music is a combination of Uruguayan traditional music, bossa nova, pop and electronic music, which results in personal compositions with original arrangements. The words play an important role in his songs. Apart from love, reflections about identity and religions are a constant in his work. Drexler was married to singer-songwriter Ana Laan, his girlfriend is Spanish actress/singer Leonor Watling. Watling is in the band Marlango, his cousin is the scientist Alejandra Melfo. Aside from his Academy Award for Best Original Song, Drexler has been nominated five times at the Grammy Awards, for the albums Eco, 12 Segundos de Oscuridad, Cara B, Bailar en la Cueva, Salvavidas de Hielo.
For his work writing Spanish-language versions of singles by Colombian singer-songwriter Shakira, he has received five ASCAP Latin Awards. Drexler received a Goya Award in 2010 with the song "Que El Soneto Nos Tome Por Sorpresa", written for the Spanish film Lope. Overall, Drexler has received 13 awards from 46 nominations. In November 2018, Drexler took home record of the year and the song of the year for "Telefonia" and the best singer-songwriter album for "Salvavidas de hielo" at the Latin Grammys 2018. La Luz Que Sabe Robar Radar Vaivén Llueve Frontera Sea Eco 12 Segundos de Oscuridad La Edad del Cielo Cara B Amar la Trama Bailar en la Cueva Salvavidas de Hielo
The RRG Storch V was the only member of Alexander Lippisch's Storch series of tailless aircraft to be powered. It flew in 1929. Before the Storch V, Lippisch had designed only gliders, many of them tailless; the first of these, the Espenlaub E.2, was built by Espenlaub in 1922 but Lippisch, at RRG from 1925, did not return to the tailless layout until 1927. Development progressed with a series of the Storch models; the Storch V was the Storch IV with a small pusher configuration engine added behind the pilot. The Storch V had a straight edged wing with about 17° of sweep on the leading edge and with only slight taper and dihedral, it was built around a plywood skinned D-box leading edge spar and a second spar near mid-chord and was fabric covered. Broad, lobate ailerons were hinged at right angles to the line of flight, protruding beyond the trailing edges and carrying small trim tabs not fitted to the Storch IV. Broad, low endplate fins and rudders of about equal area, cambered on their inner surfaces provided directional stability and control.
Their profiles were lower and simpler than those on the Storch IV. The rudders could work together in opposition for braking; each wing was braced from a single point on the lower fuselage pod longeron to nose and rear spars at about 40% span by a faired V-strut. There were a pair of sturdy, vertical struts between the upper pod and the wing centre; the pod was flat sided, with angled upper and lower surfaces and on the Storch IV projected back to a line between the aileron trailing edges to provide some yaw stability. On the Storch V this provided a place to mount a small DKW 5–7 kW air-cooled two-stroke engine in pusher configuration with its output shaft just lower than the wing. Enclosed within a humped, metal cowling, it proved difficult to cool, so it was run at less than full power. There was a landing skid under the pod which extended back past the end of the pod to protect the propeller; the date of the first flight of the Storch V is not known but it was active during 1929 and flew well despite its low engine power.
It crashed whilst demonstrating at Darmstadt in gusty conditions. Data from L'Aerophile February 1930, p.39General characteristics Crew: One Length: 3.80 m Wingspan: 12.37 m Height: 2.0 m Wing area: 18.5 m2 Aspect ratio: 8 Empty weight: 170 kg Powerplant: 1 × DKW 500 cm3 air-cooled 2-stroke piston engine, 5.2–6.7 kW Propellers: 2-bladed RRG, 1.24 m diameterPerformance Maximum speed: 125 km/h at 100 m
Protocol to the 1979 Convention on Long-Range Transboundary Air Pollution Concerning the Control of Emissions of Nitrogen Oxides or Their Transboundary Fluxes, opened for signature on 31 October 1988 and entered into force on 14 February 1991, was to provide for the control or reduction of nitrogen oxides and their transboundary fluxes. It was concluded in Bulgaria. Parties: Albania, Belarus, Bulgaria, Croatia, Czech Republic, Estonia, European Union, France, Greece, Ireland, Liechtenstein, Luxembourg, North Macedonia, Poland, Slovakia, Spain, Switzerland, United Kingdom, United States. Convention on Long-Range Transboundary Air Pollution environmental agreements This article incorporates public domain material from the CIA World Factbook document: "2003 edition". Text. Ratifications
Waldeck is a small town in Waldeck-Frankenberg district in northwestern Hesse, Germany. Waldeck lies on a man-made lake. Waldeck's constituent communities stretch from the shore of the Edersee into the Langer Wald. Waldeck borders in the north on the community of Twistetal, in the northeast on the town of Bad Arolsen, in the east on the towns of Wolfhagen and Naumburg, in the south on the community of Edertal, in the west on the community of Vöhl and the town of Korbach; the town of Waldeck consists of the centres of Alraft, Freienhagen, Höringhausen, Nieder-Werbe, Ober-Werbe, Sachsenhausen and Waldeck. The first evidence of settlement at Waldeck comes from the year 1232 when a document from the Netze Monastery mentioned the universitas civitatis de waldeke; until 1254, the town was called Rode because there was a clearing there. The town's first seal was acquired in 1266, the town had its first verifiable mayor in 1311; until the beginning of the 20th century, Waldeck's population exceeded 400.
Waldeck was the residence of the Counts of Waldeck who, beginning around 1200 gathered a sizeable realm under their control and, having added the county of Pyrmont to their holdings through inheritance, were elevated to Princes of Waldeck-Pyrmont in 1712. In 1655, the residence was transferred to Arolsen, Waldeck lost its importance; the Edersee, Germany's third largest reservoir, was created by the construction of the Eder dam in 1914. The dam, designed to help regulate water levels for shipping on the Weser and to generate hydroelectricity, was destroyed by the RAF on 17 May 1943, causing massive flooding and loss of life downstream, but was rebuilt; until municipal reforms in 1974, Freienhagen was a town in its own right. It had town rights when history first mentioned the town in 1253. On the Hünenburg, a 472 m-high mountain in the Freienhagen Municipal Forest, traces of a prehistoric settlement have been found. In the Middle Ages, Freienhagen had a complete ring of walls with two town gates through which led the old trade road from Cologne to Leipzig.
Interesting is the Freienhagen Free Court, which sat at first at the Schiebenscheid and under the linden tree at the Steinborn. Under the Free Counts Sigmund Manegold and Johann Manhoff, the court reached its greatest importance: the Teutonic Knights, the cities of Frankfurt and Cologne, were referred to Freienhagen; as part of municipal reforms, the greater town of Waldeck was formed out of the independent communities of Alraft, Höringhausen, Nieder-Werbe, Selbach and Waldeck. In 1974, Dehringhausen and Ober-Werbe joined the town; the town council's 31 seats are apportioned thus, in accordance with municipal elections held on 6 March 2016: Note: FWG is a citizens' coalition. The town's executive consists of 7 councillors. Three of these seats are held by the SPD, 2 by the CDU, one seat each by the FWG and the FDP. At the mayoral election on 22 October 2000, the SDP's Peter Brandenburg was elected Waldeck's mayor with an 80.9% share of the vote. In 2006 Jörg Feldmann was elected mayor, he was reelected in 2012.
The official blazon translates thus: In Or a six-pointed star sable. This describes a black six-pointed star on a gold background, with no mention at all of the fleur-de-lys. Furthermore, Waldeck's official Internet presence does not contain any text about the civic coat of arms, although it does display the version with the lily. At least one source, shows arms for Waldeck matching the blazon. According to this same source, the star was eight-pointed, as appears in many civic arms in the Waldeck region, it is an heraldic charge once borne by the Counts of Waldeck in the Middle Ages. The number of points was changed in the 19th century to distinguish the town's arms from the district's. Blankenhain, since 1990 Heimatmuseum Höringhausen Dorfstube Nieder-Werbe Schloss Waldeck, stately home, the town's landmark Netze monastery church with an altar from the 14th century Sachsenhäuser Warte Edertalsperre Romanesque "fortress church" with onion domes in Freienhagen half-timbered houses in Freienhagen Old mills near Freienhagen Uferpromenade Waldeck Golf courses north of town: 18-hole championship course and 9-hole short course Through the town run the Federal Highways B 251 and B 485.
Operations on the stretch of the Ederseebahn railway line between Bad Wildungen and Korbach, on which lies Waldeck, ceased on 27 May 1995. There is a cableway to the Edersee and well built hiking trails in the Kellerwald-Edersee National Park. Waldeck Schloss Waldeck Edersee holiday region History of the Principality of Waldeck Waldeck at Curlie
DNA methylation is a biological process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence; when located in a gene promoter, DNA methylation acts to repress gene transcription. In mammals, DNA methylation is essential for normal development and is associated with a number of key processes including genomic imprinting, X-chromosome inactivation, repression of transposable elements and carcinogenesis. Two of DNA's four bases and adenine, can be methylated. Cytosine methylation is widespread in both eukaryotes and prokaryotes though the rate of cytosine DNA methylation can differ between species: 14% of cytosines are methylated in Arabidopsis thaliana, 4 to 8% in Physarum, 7.6% in Mus musculus, 2.3% in Escherichia coli, 0.03% in Drosophila, 0.006% in Dictyostelium and none in Caenorhabditis or yeast species such as Saccharomyces cerevisiae and S. pombe. Adenine methylation has been observed in bacterial, in mammalian DNA, but has received less attention.
Methylation of cytosine to form 5-methylcytosine occurs at the same 5 position on the pyrimidine ring where the DNA base thymine's methyl group is located. Spontaneous deamination of 5-methylcytosine converts it to thymine; this results in a T:G mismatch. Repair mechanisms correct it back to the original C:G pair; this misincorporated base will not be corrected during DNA replication. If the mismatch is not repaired and the cell enters the cell cycle the strand carrying the T will be complemented by an A in one of the daughter cells, such that the mutation becomes permanent; the near-universal replacement of uracil by thymine in DNA, but not RNA, may have evolved as an error-control mechanism, to facilitate the removal of uracils generated by the spontaneous deamination of cytosine. DNA methylation as well as many of its contemporary DNA methyltransferases have been thought to evolve from early world primitive RNA methylation activity and is supported by several lines of evidence. In plants and other organisms,'DNA' methylation is found in three different sequence contexts: CG, CHG or CHH.
In mammals however, DNA methylation is exclusively found in CpG dinucleotides, with the cytosines on both strands being methylated. Non-CpG methylation can however be observed in embryonic stem cells, has been indicated in neural development. Furthermore, non-CpG methylation has been observed in hematopoietic progenitor cells, it occurred in a CpApC sequence context; the DNA methylation landscape of vertebrates is particular compared to other organisms. In mammals, around 75% of CpG dinucleotides are methylated in somatic cells, DNA methylation appears as a default state that has to be excluded from defined locations. By contrast, the genome of most plants, fungi, or protists show “mosaic” methylation patterns, where only specific genomic elements are targeted, they are characterized by the alternation of methylated and unmethylated domains. High CpG methylation in mammalian genomes has an evolutionary cost because it increases the frequency of spontaneous mutations. Loss of amino-groups occurs with a high frequency for cytosines, with different consequences depending on their methylation.
Methylated C residues spontaneously deaminate to form T residues over time. In mammals, the only exception for this global CpG depletion resides in a specific category of GC- and CpG-rich sequences termed CpG islands that are unmethylated and therefore retained the expected CpG content. CpG islands are defined as regions with 1) a length greater than 200bp, 2) a G+C content greater than 50%, 3) a ratio of observed to expected CpG greater than 0.6, although other definitions are sometimes used. Excluding repeated sequences, there are around 25,000 CpG islands in the human genome, 75% of which being less than 850bp long, they are major regulatory units and around 50% of CpG islands are located in gene promoter regions, while another 25% lie in gene bodies serving as alternative promoters. Reciprocally, around 60-70% of human genes have a CpG island in their promoter region; the majority of CpG islands are constitutively unmethylated and enriched for permissive chromatin modification such as H3K4 methylation.
In somatic tissues, only 10% of CpG islands are methylated, the majority of them being located in intergenic and intragenic regions. DNA methylation was present at some extent in early eukaryote ancestors. In every organism analyzed, methylation in promoter regions correlates negatively with gene expression. CpG-dense promoters of transcribed genes are never methylated, reciprocally, transcriptionally silent genes do not carry a methylated promoter. In mouse and human, around 60–70% of genes have a CpG island in their promoter region and most of these CpG islands remain unmethylated independently of the transcriptional activity of the gene, in both differentiated and undifferentiated cell types. Of note, whereas DNA methylation of Cp
Ni una menos is an Argentine fourth-wave grassroots feminist movement, which has spread across several Latin American countries, that campaigns against gender-based violence. In its official website, Ni una menos defines itself as a "collective scream against machista violence." The campaign was started by a collective of Argentine female artists and academics, has grown into "a continental alliance of feminist forces". The movement holds protests against femicides, but has touched on topics such as gender roles, sexual harassment, gender pay gap, sexual objectification, legality of abortion, sex workers' rights and transgender rights; the movement became nationally recognized with the use of the hashtag #NiUnaMenos on social media, title under which massive demonstrations were held on June 3, 2015, having the Palace of the Argentine National Congress as a main meeting point. The protest was organized after the murder of 14-year-old Chiara Paez, found buried underneath her boyfriend's house on May 11, beaten to death and a few weeks pregnant.
A viral phenomenon which extended to countries such as Uruguay and Chile, it managed to congregate around 200,000 people in Buenos Aires alone. On June 3, 2016 the multitudinous demonstration took place once again throughout Argentina's most important cities, under the new slogan #VivasNosQueremos. A #NiUnaMenos march took place in Lima, Peru on August 13, 2016, with thousands of people gathering in front of the Palace of Justice. Newspaper La República considered it the largest demonstration in Peruvian history. On October 19, 2016 the Ni una menos collective organized a first-ever women mass strike, in response to the murder of 16-year-old Lucía Pérez, raped and impaled in the coastal city of Mar del Plata, it consisted of a one-hour pause from work and study early in the afternoon, with protesters dressed in mourning for what was known as Miércoles negro. These protests became region-wide and gave the movement a greater international momentum, with street demonstrations taking place in Chile, Bolivia, Uruguay, El Salvador, Guatemala and Spain.
A week a protest took place in Rio de Janeiro, considered "yet another clear sign that Ni una menos has become a rallying cry for the region." On March 8, 2017, Ni una menos took part of the International Women's Strike. The strike was spearheaded in the United States by the leaders of the Women's March on Washington, who in a call to arms letter in The Guardian pointed to Ni una menos as an inspiration. In 2016, Argentine scientists Julián Petrulevicius and Pedro Gutiérrez named Tupacsala niunamenos, a dragonfly species found in La Rioja, after the movement; the genus Tupacsala was chosen in honor of Túpac Amaru II and Milagro Sala's organization named after him. The collective takes its name from a 1995 phrase by Mexican poet and activist Susana Chávez, "Ni una muerta más", in protest to the female homicides in Ciudad Juárez. Chávez herself was assassinated in 2011, moment in which the phrase became a "symbol of struggle"; the first protest organized by Ni una menos was held in Recoleta, Buenos Aires on March 26, 2015, consisted of a reading marathon, performance art and screenings.