Jozef De Kesel is a Belgian prelate of the Catholic Church who was Archbishop of Mechelen-Brussels from 2015 to 2023, where he had been auxiliary bishop from 2002 to 2010. He served as Bishop of Bruges from 2010 to 2015 and has been a cardinal since 2016.

The Archdiocese of Mechelen–Brussels is a Latin Church ecclesiastical territory or archdiocese of the Catholic Church in Belgium. It is the primatial see of Belgium and the centre of the ecclesiastical province governed by the Archbishop of Mechelen–Brussels, which covers the whole of Belgium. It was formed in 1559 and the bishop has a seat in two cathedrals, St. Rumbold's Cathedral in Mechelen and the Cathedral of St. Michael and St. Gudula in Brussels. The current archbishop is Luc Terlinden, who was installed in September 2023.