Fra' Juan de Homedes y Coscón was a Spanish knight of Aragon who served as the 47th Grand Master of the Order of Malta, between 1536 and 1553.

The Invasion of Gozo took place in July 1551, and was accomplished by the Ottoman Empire against the island of Gozo, following an unsuccessful attempt to conquer nearby Malta on 18 July 1551. It was followed by a victorious campaign with the siege of Tripoli.