In early July 2022, 62 of the United Kingdom's 179 government ministers, parliamentary private secretaries, trade envoys, and party vice-chairmen resigned from their positions in the second administration formed by Boris Johnson as Prime Minister, culminating in Johnson's resignation on 7 July. Johnson's premiership had been considered in danger for months after several scandals, but it was the Chris Pincher scandal that was identified to have spurred on the resignations. Considered the "last straw" for the Prime Minister, the scandal arose after it was revealed that Johnson had promoted his Deputy Chief Government Whip Chris Pincher, who was publicly facing multiple allegations of sexual assault, to the position despite knowing of the allegations beforehand.

The second Johnson ministry began on 16 December 2019, three days after Boris Johnson's audience with Queen Elizabeth II where she invited him to form a new administration following the 2019 general election. The Conservative Party was returned to power with a majority of 80 seats in the House of Commons. Initially the ministers were largely identical to those at the end of the first Johnson ministry, but changed significantly in cabinet reshuffles in February 2020 and September 2021.