Junípero Serra High School is a Catholic college preparatory high school in San Mateo, California, United States, serving students in grades 9–12. A part of the Roman Catholic Archdiocese of San Francisco, this school provides education for young men. The school has an academic focus with a college preparatory curriculum.

San Mateo is a city in San Mateo County, California, United States, on the San Francisco Peninsula. About 20 miles (32 km) south of San Francisco, the city borders Burlingame to the north, Hillsborough to the west, San Francisco Bay and Foster City to the east and Belmont to the south. The population was 105,661 at the 2020 census.