Kafue is a town on the T2 road in the Lusaka Province of Zambia and it lies on the north bank of the Kafue River, after which it is named. It is the southern gateway to the central Zambian plateau on which Lusaka and the mining towns of Kabwe and the Copperbelt are located.

The T2 is a trunk road in Zambia. The road runs from the Tunduma border with Tanzania via Mpika, Kabwe and Lusaka to the Chirundu border with Zimbabwe. The road is the longest route of the country, as it is approximately 1,155 kilometres (718 mi). The route from Mpika to Kafue is a toll road. The route from Tanzania to Lusaka is Zambia's Great North Road and is part of the Tanzam Highway.