Kakegawa Domain was a feudal domain under the Tokugawa shogunate of Edo period Japan. The domain was centered at Kakegawa Castle in Tōtōmi Province, in what is now the city of Kakegawa, Shizuoka.

Kakegawa Castle is a hirayama-style Japanese castle. It was the seat of various fudai daimyō clans who ruled over Kakegawa Domain, Tōtōmi Province, in what is now central Kakegawa, Shizuoka Prefecture, Japan.