Karachi Harbour is a narrow bay and river estuary located west of the Indus River Delta in Karachi, Pakistan. The harbour lies between the Lyari River delta and Chinna Creek to the north, and the Arabian Sea to the south. Since 1886, sections of the harbour have been improved to form the Port of Karachi - Pakistan's busiest seaport.

Karachi is the capital city of the Pakistani province of Sindh. It is the largest city in Pakistan and the 12th largest in the world, with a population of over 20 million. It is situated at the southern tip of the country along the Arabian Sea coast and formerly served as the capital of Pakistan. Ranked as a beta-global city, it is Pakistan's premier industrial and financial centre, with an estimated GDP of over $200 billion (PPP) as of 2021. Karachi is a metropolitan city and is considered Pakistan's most cosmopolitan city, and among the country's most linguistically, ethnically-, and religiously-diverse regions, as well as one of the country's most progressive and socially liberal cities.