The Karachi Port Trust (KPT) (Urdu: ادارہِ تولیتِ بندرگاہ کراچی) is a Pakistani federal government agency, under the administrative control of the Federal Maritime Secretary that oversees the operations of the Port of Karachi, one of South Asia's largest and busiest deep-water seaports which handles over 90% of the nation's foreign trade. The agency is headquartered at the colonial-era Karachi Port Trust Building.

The Port of Karachi is one of South Asia's largest and busiest deep-water seaports, handling about 60% of the nation's cargo located in Karachi, Pakistan. It is located on the Karachi Harbour, between Kiamari Azra Langri, Manora, and Kakapir, and close to Karachi's main business district and several industrial areas. The geographic position of the port places it in close proximity to major shipping routes such as the Strait of Hormuz. It is also ideally located to offer gateway services to the maritime trade for the Central Asian Republics (CARs). The administration of the port is carried out by the Karachi Port Trust, which was established in 1857.