Karel Abraham is a retired motorcycle racer from the Czech Republic. He competed in Grand Prix motorcycle racing from 2005 to 2019, riding in the 125cc, 250cc, Moto2 and MotoGP classes, with the exception of 2016, when he raced in the Superbike World Championship. In 2010 he won the Moto2 Valencian Grand Prix and finished third at Twin Ring Motegi in the same class. His father, also called Karel Abraham, has owned Brno Circuit since December 2005.

The 2019 FIM MotoGP World Championship was the premier class of the 71st F.I.M. Road Racing World Championship season.