Karen Hollins is a fictional character from the BBC soap opera Doctors, portrayed by Jan Pearson. Introduced as a receptionist at the fictional Mill Health Centre, Karen was created by series producer Peter Eryl Lloyd as a replacement for former receptionist Vivien March. She first appeared during the episode broadcast on 23 February 2009. Writers eventually introduced a family for Karen; husband and police sergeant Rob, and their children, Imogen and Jack. Karen is depicted as a hardworking person who cares about her job and the patients at the surgery, but someone who prioritises her family above her work responsibilities.

Doctors is a British medical soap opera, first broadcast on BBC One on 26 March 2000. Filmed in Birmingham and set in the fictional West Midlands town of Letherbridge, the soap follows the lives of the staff of both an NHS doctor's surgery and a university campus surgery, as well as the lives of their families and friends. Initially, only 41 episodes of the programme were ordered, but due to the positive reception, the BBC ordered it as a continuing soap opera. Doctors was filmed at the Pebble Mill Studios until 2004; production then relocated to the BBC Drama Village, where it will film until 2024. Episodes are filmed three months prior to transmission. The soap is typically broadcast on weekdays at 1:45 pm on BBC One, as well as having classic episodes broadcast on Drama. It takes three annual transmission breaks across the year: at Easter, during the summer and at Christmas.