Karen Vilhelmi Karapetyan is an Armenian politician who was Prime Minister of Armenia from September 2016 until April 2018. He was previously Mayor of Yerevan, the capital, from 2010 to 2011. He was appointed prime minister by President Serzh Sargsyan on 13 September 2016 and held office until 9 April 2018. Karapetyan served as first deputy prime minister from 17 April to 23 April 2018, when he was appointed acting prime minister following the resignation of Prime Minister Serzh Sargsyan. He held this position until the election of Nikol Pashinyan as prime minister on 8 May 2018.

The prime minister of Armenia is the head of government and most senior minister within the Armenian government, and is required by the constitution to "determine the main directions of policy of the Government, manage the activities of the Government and coordinate the work of the members of the Government." Also, according to the constitution, the prime minister heads the Security Council, which prescribes the main directions of the country's defense policy; thus, the prime minister is effectively the commander-in-chief of the Armed Forces of Armenia. Nikol Pashinyan is the current prime minister. He took the office on 8 May 2018 following the resignation of Serzh Sargsyan.