Karen Sisco is an American crime drama television series starring Carla Gugino in the title role. The series was created by novelist Elmore Leonard, based on a character who had appeared in several of his written works, as well as one film adaptation, 1998's Out of Sight. The series debuted on October 1, 2003 on ABC, and was canceled after ten episodes, with Gugino later reprising her role from the series in a 2012 third season episode of Justified.

Carla Gugino is an American actress. After early roles in the films Troop Beverly Hills (1989), This Boy's Life (1993), Son in Law (film) (1993), and Snake Eyes (1998), Gugino received wider recognition for her starring roles in the Spy Kids trilogy (2001–2003), Sin City (2005), Night at the Museum (2006), American Gangster (2007), Righteous Kill (2008), Race to Witch Mountain (2009), Sally Jupiter in Watchmen (2009), Sucker Punch (2011), Mr. Popper's Penguins (2011), San Andreas (2015), Gerald's Game (2017), and Gunpowder Milkshake (2021).