Karen Valentine is an American actress. She is best known for her role as young idealistic schoolteacher Alice Johnson in the ABC comedy drama series Room 222 from 1969 to 1974, for which she won the Primetime Emmy Award for Outstanding Supporting Actress in a Comedy Series in 1970, and received a Golden Globe Award nomination in 1971. She later went to star in her own short-lived sitcom Karen (1975), and played leading roles in the Disney films Hot Lead and Cold Feet (1978) and The North Avenue Irregulars (1979).

Room 222 is an American comedy-drama television series produced by 20th Century Fox Television that aired on ABC for 112 episodes, from September 17, 1969, until January 11, 1974. The show was broadcast on Wednesday evenings at 8:30 (ET) for its first two seasons, before settling into Friday evenings at 9:00, following The Brady Bunch and The Partridge Family, and preceding The Odd Couple and Love, American Style.