Karijini National Park is an Australian national park centred in the Hamersley Ranges of the Pilbara region in the northwestern section of Western Australia. The park is located north of the Tropic of Capricorn, 1,055 kilometres (656 mi) from the state's capital city, Perth. Formerly known as Hamersley Range National Park, the park was officially renamed in 1991.

The Hamersley Range is a mountainous region of the Pilbara region of Western Australia. The range was named on 12 June 1861 by explorer Francis Thomas Gregory after Edward Hamersley, a prominent promoter of his exploration expedition to the northwest. Karijini National Park lies within the range.