Karine Vanasse is a French-Canadian actress, who had roles in the films Polytechnique, Séraphin: Heart of Stone , Switch and Set Me Free (Emporte-moi). Internationally she is best known for her roles as Colette Valois in Pan Am, Margaux LeMarchal in Revenge and Lise Delorme in Cardinal.

Polytechnique is a 2009 Canadian drama film directed by Denis Villeneuve and written by Villeneuve and Jacques Davidts. Starring Maxim Gaudette, Sebastien Huberdeau, and Karine Vanasse, the film is based on the 1989 École Polytechnique massacre and re-enacts the events of the incident through the eyes of two students who witness a gunman (Gaudette) murder fourteen young women.