Karl H. Pribram was a professor at Georgetown University, in the United States, an emeritus professor of psychology and psychiatry at Stanford University and distinguished professor at Radford University. Board-certified as a neurosurgeon, Pribram did pioneering work on the definition of the limbic system, the relationship of the frontal cortex to the limbic system, the sensory-specific "association" cortex of the parietal and temporal lobes, and the classical motor cortex of the human brain. He worked with Karl Lashley at the Yerkes Primate Center of which he was to become director later. He was professor at Yale University for ten years and at Stanford University for thirty years.

Holonomic brain theory is a branch of neuroscience investigating the idea that human consciousness is formed by quantum effects in or between brain cells. Holonomic refers to representations in a Hilbert phase space defined by both spectral and space-time coordinates. Holonomic brain theory is opposed by traditional neuroscience, which investigates the brain's behavior by looking at patterns of neurons and the surrounding chemistry.