Karnes County is a county in the U.S. state of Texas. As of the 2020 census, the population was 14,710. Its county seat is Karnes City. The county is named for Henry Karnes, a soldier in the Texas Revolution. The former San Antonio and Aransas Pass Railway passed through Karnes County in its connection linking San Antonio with Corpus Christi.

Coastal Bend College (CBC), formerly Bee County College, is a public community college that has its main campus in Beeville, Texas, and branch campuses in Alice, Kingsville, and Pleasanton, Texas.