Kasese is a town in the Western Region of Uganda. It is the capital of Kasese District. Kasese is also the largest town in the Rwenzururu region. In 2020 it had an estimated population 115,400. It lies north of Lake George and east of Rwenzori Mountains.

The Western Region of Uganda is one of four regions in the country of Uganda. As of Uganda's 2014 census, the Western region's population was 8,874,862.