Katavi Region is one of Tanzania's 31 administrative regions. The region covers an area of 45,843 km2 (17,700 sq mi). The region is comparable in size to the combined land area of the nation state of Estonia. Katavi Region is bordered to the east by Tabora Region. The region is bordered to the south by Rukwa Region and Songwe Region. Lastly, Katavi borders DRC on Lake Tanganyika to the west. The region derives its name from Katavi, the spirit of lake Tanganyika. The regional capital city is Mpanda. According to the 2022 national census, the region had a population of 1,152,958.

Rukwa Region(Mkoa wa Rukwa in Swahili) is one of Tanzania's 31 administrative regions The region covers a land area of 27,765 km2 (10,720 sq mi). The region is comparable in size to the combined land area of the nation state of Haiti. Rukwa Region is bordered to the north by Katavi Region, to the east by Songwe Region, to the south by the nation of Zambia and to the west by Lake Tanganyika, which forms a border between Tanzania and the Democratic Republic of the Congo. The regional capital is the municipality of Sumbawanga. According to the 2022 national census, the region had a population of 1,540,519.