Katharine Smith Reynolds, later Katharine Smith Johnston, was the wife of tobacco tycoon R. J. Reynolds and a philanthropist who designed the Reynolda House estate.

The Reynolda House Museum of American Art displays a premiere collection of American art ranging from the colonial period to the present. Built in 1917 by Katharine Smith Reynolds and her husband R. J. Reynolds, founder of the R. J. Reynolds Tobacco Company, the house originally occupied the center of a 1,067-acre (4.32 km2) estate. It opened to the public as an institution dedicated to the arts and education in 1965, and as an art museum in 1967. The house holds one of the country's finest collections of American paintings. It is located in Winston-Salem, North Carolina.