The House of Keșco or Cheșco/Keșcu/Cheșcu, was the name of an ancient Moldavian Boyar noble family whose members held significant positions in Moldavia and later in the Russian Empire and Romania. Most notable member was Natalia Keshko, who became first modern Queen of Serbia.

Natalija Obrenović, née Keshko, known as Natalie of Serbia, was the Princess of Serbia from 1875 to 1882 and then Queen of Serbia from 1882 to 1889 as the wife of Milan I of Serbia.