The Keeper of the Great Seal of Scotland is the keeper of the Great Seal of Scotland, and one of the great officers of state in Scotland. The Keeper of the Great Seal of Scotland is the incumbent First Minister of Scotland, formally the First Minister and Keeper of the Scottish Seal, a role currently held by John Swinney since 8 May 2024.

The Great Seal of Scotland is a principal national symbol of Scotland that allows the monarch to authorise official documents without having to sign each document individually. Wax is melted in a metal mould or matrix and impressed into a wax figure that is attached by cord or ribbon to documents that the monarch wishes to make official. The earliest seal impression, in the Treasury of Durham Cathedral, is believed to be the Great Seal of Duncan II and dates to 1094.