Keahikuni Kekauʻōnohi was a Hawaiian high chiefess who was a member of the House of Kamehameha. She was granddaughter to King Kamehameha I and one of the wives of Kamehameha II. Her Christian name is disputed; it is given as Mikahela in the 1848 Mahele Book and as Miriam in later sources.

Kamehameha II was the second king of the Kingdom of Hawaii from 1819 to 1824. His birth name was Liholiho and full name was Kalaninui kua Liholiho i ke kapu ʻIolani. It was lengthened to Kalani Kaleiʻaimoku o Kaiwikapu o Laʻamea i Kauikawekiu Ahilapalapa Kealiʻi Kauinamoku o Kahekili Kalaninui i Mamao ʻIolani i Ka Liholiho when he took the throne.