Kellee Santiago is a Venezuelan American video game designer and producer. She is the co-founder and former president of thatgamecompany. Santiago was born in Caracas, Venezuela, and raised in Richmond, Virginia, where Santiago played video games from a young age and was encouraged by her software engineer father to experiment with computers. While attending New York University's Tisch School of the Arts, she became active in experimental theater, planning to pursue it after earning a master's degree in the Interactive Media Program of the School of Cinematic Arts at the University of Southern California. However, Santiago became involved in video game design and produced Cloud, a game developed by Jenova Chen and a student team. Its success sparked her and Chen to found thatgamecompany upon graduating, and she became the president.

Thatgamecompany, Inc. is an American independent video game development company founded by University of Southern California students Jenova Chen and Kellee Santiago in 2006. The company was a developer for Sony Computer Entertainment, contracted to create three downloadable games for the PlayStation 3's PlayStation Network service, and has since secured independent funding. The first of their games is a remake of Chen's award-winning Flash title Flow, with enhanced visuals and sound, added multiplayer modes and compatibility with the PlayStation 3's motion-sensitive controller. The title was released on the PlayStation Store in 2007. The company's second PlayStation 3 game, Flower, was released on the PlayStation Store in 2009, and their third game, Journey, was released in March 2012 on the PlayStation Store. Their fourth game, Sky: Children of the Light, was released in July 2019 on iOS and in April 2020 on Android. Later, it released on the Nintendo Switch in June 2021 and on PlayStation 4 in December 2022.