The Kennedy curse is a series of deaths, accidents, assassinations, and other calamities involving members of the American Kennedy family. The alleged curse has primarily struck the descendants of businessman Joseph P. Kennedy Sr., but it has also affected family friends, associates, and other relatives. Political assassinations and plane crashes have been the most common manifestations of the "curse". Following the Chappaquiddick incident in 1969, Ted Kennedy is quoted saying he questioned if "some awful curse did actually hang over all the Kennedys." However skeptics argue that it is not improbable for a large extended family to experience similar events over the course of several generations.

The Kennedy family is an American political family that has long been prominent in American politics, public service, entertainment, and business. In 1884, 35 years after the family's arrival from County Wexford, Ireland, Patrick Joseph "P. J." Kennedy became the first Kennedy elected to public office, serving in the Massachusetts state legislature until 1895. At least one Kennedy family member served in federal elective office from 1947, when P. J. Kennedy's grandson John F. Kennedy became a member of Congress from Massachusetts, until 2011, when Patrick J. Kennedy II retired as a member of the U.S. House of Representatives from Rhode Island.