The Kentucky & Indiana Bridge is one of the first multi modal bridges to cross the Ohio River. It is for both railway and common roadway purposes together. Federal, state, and local law state that railway, streetcar, wagon-way, and pedestrian modes of travel were intended by the cites of New Albany and Louisville, the states of Kentucky and Indiana, the United States Congress, and the bridge owners. The K&I Bridge connects Louisville, Kentucky, to New Albany, Indiana. Constructed from 1881 to 1885 by the Kentucky and Indiana Bridge Company, the original K&I Bridge opened in 1886. It included a single standard gauge track and two wagon ways, allowing wagons and other animal powered vehicles to cross the Ohio River by a method other than ferry for the first time. At that time, motorized vehicles were virtually nonexistent. The K&I Bridge company also owned a ferry boat operation during both the first and second bridge; eventually that operation was sold as the bridge's success largely outmoded boat usage.

U.S. Route 150 (US 150) in Indiana is a 176.315-mile-long (283.751 km) east–west highway that travels from the Illinois state line east of Paris, Illinois to Louisville, Kentucky at the Kentucky state line. A section of US 150 from New Goshen to Vincennes travels north–south instead of east–west. US 150 travels concurrently with its parent route, US 50, from Vincennes to Shoals. Between West Terre Haute and Terre Haute, US 150 travels along part of the historic National Road. Also, from Vincennes to New Albany, the route is designated as part of Indiana's Historic Pathways, as it roughly parallels what was then part of the Buffalo Trace.