Kentucky Lake is a major navigable reservoir along the Tennessee River in Kentucky and Tennessee. It was created in 1944 by the Tennessee Valley Authority's impounding of the Tennessee River via Kentucky Dam for flood control and hydroelectric power. The 160,309-acre (649 km2) lake is the largest artificial lake by surface area in the United States east of the Mississippi River, with 2,064 miles (3,322 km) of shoreline. Kentucky Lake has a flood storage capacity of 4,008,000 acre⋅ft (4.944 km3), more than 2.5 times the next largest lake in the TVA system.

The Tennessee River is the largest tributary of the Ohio River. It is approximately 652 miles (1,049 km) long and is located in the southeastern United States in the Tennessee Valley. The river was once popularly known as the Cherokee River, among other names, as the Cherokee people had their homelands along its banks, especially in what are now East Tennessee and northern Alabama. Additionally, its tributary, the Little Tennessee River, flows into it from Western North Carolina and northeastern Georgia, where the river also was bordered by numerous Cherokee towns. Its current name is derived from the Cherokee town, Tanasi, which was located on the Tennessee side of the Appalachian Mountains.