Kentucky Route 259 is a 95.91-mile-long (154.35 km) state highway that traverses five counties in west-central Kentucky.

U.S. Route 68 is a United States highway that runs for 560 miles (900 km) from northwest Ohio to Western Kentucky. The highway's western terminus is at US 62 in Reidland, Kentucky. Its present northern terminus is at Interstate 75 in Findlay, Ohio, though the route once extended as far north as Toledo. US 68 intersects with US 62 three times during its route.