Kernville is a census-designated place (CDP) in the southern Sierra Nevada, in Kern County, California, United States. Kernville is located 42 miles (68 km) northeast of Bakersfield, at an elevation of 2,667 feet (813 m). The population was 1,549 at the 2020 United States census, up from 1,395 at the 2010 census, but below the 2000 census total of 1,736.

The Kern River, previously Rio de San Felipe, later La Porciuncula, is an Endangered, Wild and Scenic river in the U.S. state of California, approximately 165 miles (270 km) long. It drains an area of the southern Sierra Nevada mountains northeast of Bakersfield. Fed by snowmelt near Mount Whitney, the river passes through scenic canyons in the mountains and is a popular destination for whitewater rafting and kayaking. It is the southernmost major river system in the Sierra Nevada, and is the only major river in the Sierra that drains in a southerly direction.