Khatlon Region, one of the four provinces of Tajikistan, is the most populous of the four first level administrative regions. It is situated in the southwest of the country, between the Hisor (Gissar) Range in the north and the river Panj in the south and borders on Afghanistan in the southeast and on Uzbekistan in the west. During Soviet times, Khatlon was divided into Kurgan-Tyube (Qurghonteppa) Oblast – with the Kofarnihon and Vakhsh river valleys – and Kulob Oblast – with the Kyzylsu and Yakhsu river valleys. The two regions were merged in November 1992 into today's Khatlon Region. The capital city is Bokhtar, formerly known as Qurghonteppa and Kurgan-Tyube.

Bokhtar, previously known as Qurghonteppa, Kurganteppa and Kurgan-Tyube, is a city in southwestern Tajikistan, which serves as the capital of the Khatlon region. Bokhtar is the largest city in southern Tajikistan, and is located 100 kilometres (62 mi) south of Dushanbe and 150 kilometres (93 mi) north of Kunduz, Afghanistan.