Khoisan KOY-sahn, or Khoe-Sān, is a catch-all term for the indigenous peoples of Southern Africa who traditionally speak non-Bantu languages, combining the Khoekhoen and the Sān peoples. Khoisan populations traditionally speak click languages and are considered to be the historical communities throughout Southern Africa, remaining predominant until European colonisation in areas climatically unfavorable to Bantu (sorghum-based) agriculture, such as the Cape region, through to Namibia, where Khoekhoe populations of Nama and Damara people are prevalent groups, and Botswana. Considerable mingling with Bantu-speaking groups is evidenced by prevalence of click phonemes in many especially Xhosa Southern African Bantu languages.

The Bantu expansion was a major series of migrations of the original Proto-Bantu-speaking group, which spread from an original nucleus around West-Central Africa. In the process, the Proto-Bantu-speaking settlers displaced, eliminated or absorbed pre-existing hunter-gatherer and pastoralist groups that they encountered.