King Edward VI Handsworth School for Girls is a grammar school for girls aged 11–18 located in Handsworth, Birmingham, England. It is part of the Foundation of the Schools of King Edward VI. The school was founded in 1883 as King Edward's Aston on the site where its brother school, King Edward VI Aston School, remains to this day. In 2019 there were 1086 girls on roll. Pupils must pass an 11-plus entrance exam to get into the school. The King Edward Schools are fiercely competitive to get admission to, as only 1 in 10 are successful in passing the entrance exam. The King Edward VI Foundation holds its exams at the same time, and generally a candidate will sit one exam for multiple schools within the foundation. Notable leaver's destinations from this school in previous years have been Birmingham, Aston, Oxford, and Nottingham. The leavers destinations by course were mainly medicine, dentistry, law, business studies and computer science.

Handsworth is an inner-city area of Birmingham in the West Midlands, England. Historically in Staffordshire, Handsworth lies just outside Birmingham City Centre and near the town of Smethwick.