Klein High School is a public high school located in Klein, Texas, United States, located approximately 20 miles (32 km) from Downtown Houston. It serves grades 9–12 in the Klein Independent School District. The current principal of Klein High School is Shannon Strole.

Klein is an unincorporated community in Harris County, Texas, United States, roughly bordering Texas State Highway 99 to the north, Texas State Highway 249 to the west, Interstate 45 to the east, and the city of Houston to the south. It includes the entire area of Klein ISD. Residents of the zip codes 77066, 77069, 77086, 77379, 77388, 77389 and 77391 can use Klein as their postal city. Klein is one of the most diverse, as well as being one of the largest unincorporated areas of Houston.